Quadriceps Muscle Strength and Body Mass Index are Associated with Estimates of Physical Activity Postheart Transplantation

Quadriceps Muscle Strength and Body Mass Index are Associated with Estimates of Physical Activity Postheart Transplantation

Published 17th October 2018

Kelly, Rebecca L., Walsh, James R.,  Paratz, Jennifer D., Yerkovich, Stephanie T.,  McKenzie, Scott C., Morris, Norman R.

BACKGROUND Whilst exercise capacity improves postheart transplantation (HTx), it remains unclear if the level of physical activity (PA) shows similar improvement. The purpose of this study was to (1) describe PA levels and (2) identify factors which may be associated with levels of PA post-HTx.

METHODS A prospective observational cross-sectional study was conducted at a single centre HTx outpatient clinic. Medically stable adult recipients ≥6months post-HTx were recruited. Physical activity level (PAL) and average daily time spent at least moderately active (≥3 metabolic equivalents (METs)) were estimated using a multisensor device. Factors investigated were demographic (age, sex, body mass index (BMI), time post-HTx and reason for HTx), corticosteroid use, exercise capacity (6 minute walk distance) and quadriceps muscle strength corrected for body weight (QS%).

RESULTS The mean post-HTx time of the 75 participants was 9.2±7.0yrs (0.5-26yrs). Twenty-seven (36%) were classified as extremely inactive (PAL<1.40); 26 (34.6%) sedentary (1.40<PAL<1.69) and 22 (29.3%) active (PAL>1.70). Multivariable analysis showed greater QS% (β=0.004 (0.002-0.006) p=0.001) to be independently associated with increased PAL. For increased time ≥3METs both greater QS% (β=0.0164 (0.003-0.029), p=0.014) and lower BMI (β=-0.0626 (-0.115- -0.0099), p=0.021) were independently associated.

CONCLUSIONS The degree of observed sedentary behaviour post-HTx is surprising, with the majority of participants not reaching levels of PA recommended for health benefits. QS% and BMI were the only factors found to be independently associated with estimates of PA. Further quality trials are required to demonstrate the long-term benefits of regular PA and investigate ways of increasing adherence to PA post-HTx.

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